Enzyme Function Discovery

Strategies for discovery and improvement of enzyme function: state of the art and opportunities

Developments in biocatalysis have been largely fuelled by consumer demands for new products, industrial attempts to improving existing process and minimizing waste, coupled with governmental measures to regulate consumer safety along with scientific advancements. One of the major hurdles to application of biocatalysis to chemical synthesis is unavailability of the desired enzyme to catalyse the...

Metagenome—a challenging source of enzyme discovery

Evolution over very long periods of time has generated a vast pool of physiologies and molecular adaptations to enable microorganisms to thrive in a wide range of living conditions. These solutions may be valuable tools in the rational design of technical processes. However, molecular ecological studies have proven that the vast majority of microorganisms cannot be cultivated in the laboratory ...

Modeling enzyme-ligand binding in drug discovery

Enzymes are one of the most important groups of drug targets, and identifying possible ligand-enzyme interactions is of major importance in many drug discovery processes. Novel computational methods have been developed that can apply the information from the increasing number of resolved and available ligand-enzyme complexes to model new unknown interactions and therefore contribute to answer o...

Function Discovery using

Function-first antibody discovery

Therapeutic antibodies may mediate antineoplastic effects by altering the biological functions of their target, by directly stimulating the demise of cancer cells or by activating antibody-dependent immune effector mechanisms. We have recently provided in vivo proof-of-concept for a "function-first" target and drug discovery platform in which antibodies against a multitude of tumor-associated a...